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LOVASTATIN
Lovastatin is a drug, belonging to the class of 'statins', used for lowering cholesterol
in patients having hypercholesterolemia. It also helps to prevent
cardiovascular disease. The drug is absorbed from GIT. It undergoes
extensive first pass metabolism in liver which is the primary site
of action.
It is highly bound to plasma protein. Absorption is reduced by
approximately 30% when administered on an empty somach rather than
with food. Lovastatin is eliminated primarily through fecal route
which is 83% of orally administered dose. 10% of the drug is
eliminated by renal route.
Brand Name: Mevacor, Altocor, Altoprev
Iupac Name: [8-[2-(4-hydroxy-6-oxo-oxan-2-yl)ethyl]
-3, 7-dimethyl-1, 2, 3, 7, 8, 8a- hexahydronaphthalen- 1-yl]
2-methylbutanoate
Working
The drug works by blocking the body's ability to make cholesterol.
It may help reducing or lowering blood cholesterol in patients who
are at risk of getting heart disease or a stroke.
Dosage
10 to 80 mg per day in single or divided doses
Contra- Indications: Hypersensitivity, active liver disease
or unexplained persistent elevations of serum transaminases, pregnancy and nursing.
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Flatulence
- Constipation
- Nausea
- Abdominal Pain
- Cramps
- Dyspepsia
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.


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Under finished pharmaceutical formulations the drugs are manufactured
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