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Levocetirizine
Levocetrizine or
levocetirizine is a selective, long acting peripheral H1 receptor
antagonist antihistamine. The increased polarity of the drug may
decrease distribution of the drug into the CNS, resulting in reduced
potential for adverse CNS effects. Tolerance does not occur. As it
does not readily cross the blood brain barrier, it does not cause
sedation or interfere with mental alertness or memory function.
The drug is highly effective and well-tolerated anti-histamine, introduced for treating symptoms associated with seasonal allergic
rhinitis, perennial allergic rhinitis and chronic idiopathic
urticaria.
Levocetrizine, a potent single isomer of cetrizine, binds twice as
strongly to histamine H1 receptors in vitro and also has a highly
consistent and predictable anti-histamine action.
Brand Name: Xusal, Xyzal
Iupac Name:
Desloratidine2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]
piperazin-1-yl]ethoxy]acetic acid
Dosage
Adults & children above 6 years: 5mg single intake
orally
Children below 6 years: No adjusted dose
Elderly: Adjust dose on the basis of renal function
Contra- Indications: In severe renal impairment
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Headache
- Somnolence
- Dry mouth
- Mild Drowsiness
Use the drug with caution during pregnancy and lactation, as the
drug may pass into the breast milk.
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.


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