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SILDENAFIL CITRATE
Sildenafil citrate, is one of
the most commonly sold drug for treating male erectile dysfunction
or impotence. It is also used for treating pulmonary arterial
hypertension (PAH). The drug was developed by the pharmaceutical
company Pfizer.
It is a selective inhibitor of cyclic guanosine monophosphate
specific phosphodiesterase type 5 (PDE5) When the sexual stimulation
causes local release of NO, inhibition of PDE5 by sildenafil causes
incresaed loevel of cGMP in the corpus cavernosum resulting in
smooth muscle relaxation and inflow of blood to the corpus
cavernosum.
Brand Name: Viagra, Revatio
Iupac Name:
1-[4-ethoxy-3-(6, 7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4, 3-d]pyrimidin-5-yl)phenylsulfonyl]-4-methylpiperazine
citrate
Dosage
The recommended dose is 50 mg per day as needed, appx 1 hour before
sexual activity. Based on effectiveness and toleration, the dose may
be increased to a maximum recommended dose of 100 mg or decreased to
25 mg.
Contra- Indications: In patients, on nitrate therapy and
with a known hypersensitivity to any component of the tablet
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Headache
- Flushing
- Dyspepsia
- Nasal congestion
- Abnormal vision
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.


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portal gives you extensive list of the cGMP contract manufacturer of herbals and
pharmaceutical manufacturing capabilities. It also contains the valuable information
pertaining to the drug manufacturing with the names of various drugs.
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Finished Formulations:
Under finished pharmaceutical formulations the drugs are manufactured
under strict quality control for ensuring a completely safe product. The
finished formulations are available in the form of tablets, capsules, injections.
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Drugs:
Pharmaceutical Drugs are those drugs that are given under the
supervision of physicians to cure various physical disorders. They are
either prescriptive or non prescriptive.
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